1999-07-22-14 Fetal lithium effects © Jeanty www.thefetus.net/
Fetal lithium effects
Philippe Jeanty, MD, PhD & Sandra R Silva, MD
Definition: Cardiac anomaly (see below) and possible goiter due to maternal ingestion of lithium for manic-depressive disorder.
Incidence: Very rare
Etiology: Maternal exposure to lithium. A report in the 1970 associated the maternal use of lithium with Ebstein anomaly (with a 400% risk factor),,. More recent data have not supported this finding,,. The final answer is probably that there might be a very small increase, but that it is infrequent enough that it should not be the cause for discontinuing treatment.
Recurrence risk: None.
Diagnosis: Aside from the exceptional Ebstein anomaly, goiter and polyhydramnios and oromandibular-limb hypogenesis or even stillbirth have been reported.
Genetic anomaly: None
Associated anomalies: None
Differential diagnosis: None
Prognosis: Dependent on the severity of the anomaly if they exist.
Management: No alteration of management indicated.
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