2005-11-15-11 MRI, Labiopalatine cleft © Werner www.thefetus.net/
Heron Werner, MD*, Pedro Daltro, MD*, Dorothy Bulas, MD #
* Heron Werner, MD & Pedro Daltro, MD*
Clínica de Diagnóstico por Imagem (CDPI) & Instituto Fernandes Figueira (IFF) – FIOCRUZ
Rio de Janeiro – Brazil
# Dorothy I. Bullas M.D.
Professor of Radiology and Pediatrics
Children"s National Medical Center
George Washington University Medical Center
111 Michigan Ave, NW, Washington D.C. 20010
Such anomaly may occur around the fourth week of gestation. It is the result of an incomplete closure of the frontonasal process of the face with the lateral maxillary prominences. The anomaly affects the upper lip and/or the palate. It is commonly localized either to the right or the left of the median line. It may occur as an isolated malformation or as part of a multiple malformation.
The labial cleft has an incidence of 1/1.000 births and the palatine cleft has an incidence 5/1.000 births. When isolated, a labial cleft has a good outcome followed by postnatal esthetics"s correction. The median clefts may be related to some brain malformations, especially to holoprosencephaly, which is frequently associated with trisomy 13.